1405-10-3
1405-10-3 Neomycin sulfate yog tshuaj tua kab mob aminoglycoside. Cov khoom no muaj cov tshuaj tua kab mob zoo tiv thaiv kab mob Enterobacteriaceae xws li Staphylococcus (methicillin rhiab hom), Corynebacterium, Escherichia coli, Klebsiella, thiab Proteobacteria, tab sis muaj kev ua haujlwm tsis zoo tiv thaiv ...
- Khoom Taw qhia
Neomycin sulfate yog tshuaj tua kab mob aminoglycoside. Cov khoom no muaj cov tshuaj tua kab mob zoo tiv thaiv kab mob Enterobacteriaceae xws li Staphylococcus (methicillin rhiab hom), Corynebacterium, Escherichia coli, Klebsiella, thiab Proteobacteria, tab sis muaj kev ua haujlwm tsis zoo rau ntau pawg Streptococcus, Streptococcus pneumoniae, Enterococcus, thiab lwm yam. , thiab lwm yam yog resistant rau cov khoom no. Cov kab mob muaj ib feem lossis ua tiav kev tiv thaiv rau streptomycin, neomycin, kanamycin, thiab gentamicin. Kev siv cov neomycin muaj qhov tseem ceeb nephrotoxicity thiab ototoxicity, yog li tam sim no nws tsuas yog siv rau qhov ncauj lossis hauv zos.
Lub cev thiab tshuaj muaj zog
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txheeb xyuas
1. Noj li 10mg ntawm cov khoom, dissolve nws nyob rau hauv 1ml dej, ntxiv 2ml ntawm hydrochloric acid tov (9-100), sov nws nyob rau hauv ib da dej rau 10 feeb, ntxiv 2ml ntawm 8% sodium hydroxide tov thiab 1ml. ntawm 2% acetylacetone tov, sov nws hauv da dej rau 5 feeb, txias nws, ntxiv 1ml ntawm p-dimethylaminobenzaldehyde test tov, thiab nws yuav tig cherry liab.
2. Noj cov khoom no thiab tus qauv neomycin, ntxiv dej sib cais los ua cov tshuaj uas muaj 20mg ib 1ml. Raws li txoj kev nyias-txheej chromatography (Appendix VB), 1 μl ntawm txhua qhov saum toj no ob txoj kev daws teeb meem tau muab coj los ua thiab pom ntawm tib lub silica gel H nyias txheej phaj (1.5g ntawm silica gel H tau npaj los ntawm kev sib xyaw 6ml ntawm 0.25% carboxymethyl cellulose sodium tov). Cov phaj tau tsim los siv methanol ethyl acetate acetone 8.8% ammonium acetate tov (25:15:10:40) ua tus neeg sawv cev, qhuav ntawm 110 degree rau 20 feeb, thiab tom qab ntawd txau nrog 10% sodium hypochlorite tov. . Cov txheej nyias nyias tau txias rau hauv qhov chaw cua rau ib pliag, thiab tom qab ntawd txau nrog cov poov tshuaj iodide starch tov (0.5g ntawm potassium iodide hauv 100ml ntawm 0.5% hmoov txhuv nplej siab), thiab tshuaj xyuas tam sim ntawd. Cov xim thiab txoj hauj lwm ntawm lub ntsiab me ntsis ntawm cov tshuaj ntsuam xyuas yuav tsum yog tib yam li cov nyob rau hauv cov txheej txheem tov.
3. Kev txheeb xyuas cov tshuaj tiv thaiv ntawm sulfate hauv cov tshuaj aqueous ntawm cov khoom no (Appendix III).
Cim npe nrov: 1405-10-3, Tuam Tshoj 1405-10-3 Hoobkas
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